About Oyster Point
We are a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of first-in-class pharmaceutical therapies to treat ocular surface diseases.
Our lead product candidate, OC-01, a highly selective nicotinic acetylcholine receptors (nAChR) agonist, is being developed as a nasal spray to treat the signs and symptoms of dry eye disease.
Dry eye disease is a multifactorial chronic disease of the ocular surface characterized by a loss of homeostasis of the tear film, resulting in pain, visual impairment, tear film hyperosmolarity and instability, inflammation and corneal wounding.1 More than 340 million adults globally and approximately 34 million adults in the United States are estimated to suffer from dry eye disease.2,3
OC-01 (varenicline) nasal spray’s novel mechanism of action is designed to re-establish tear film homeostasis by activating the trigeminal parasympathetic pathway and stimulating the glands and cells responsible for natural tear film production. Human tear film is a complex mixture of more than 1,500 different proteins, including growth factors and antibodies, as well as numerous classes of lipids and mucins. This complex tear film coats the surface of the eye and is responsible for forming the primary refractive surface of the cornea, as well as protecting and moisturizing the cornea. The Lacrimal Functional Unit (LFU), controlled by the parasympathetic nervous system, is comprised of glands and cells that are responsible for producing the mucin and aqueous layers, also referred to as the “muco-aqueous” layer, and the lipid layer that comprise healthy tear film. To stimulate the LFU, we are targeting a class of receptors called nicotinic acetylcholine receptors (nAChR) that are located on the trigeminal nerve and readily accessible within the anterior nasal cavity.
We plan to leverage our nAChR domain expertise to disrupt how ocular surface diseases are treated.